Name | 2-(3-Hydroxy-4-methoxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one |
Synonyms | Tamarixin Tamarixetin 3-O-glucoside 4'-O-methylquercetin-3-O-β-D-glucopyranoside 3-(β-D-Glucopyranosyloxy)-3',5,7-trihydroxy-4'-methoxyflavone 3',5,7-Trihydroxy-3-[(β-D-glucopyranosyl)oxy]-4'-methoxyflavone 2-(3-Hydroxy-4-methoxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)- |
CAS | 27542-39-8 |
Molecular Formula | C22H22O12 |
Molar Mass | 478.41 |
Storage Condition | 2-8℃ |
Introduction | Azadirachta indica is a famous medicinal and insecticidal plant. Yadav D K et al. reported that Tamarix -3-o-glucoside, Tamarix -3-o-glucoside, which can be extracted from Azadirachta indica leaves with methanol, has gastric protective activity in animal models. |
Application | tamarixin-3-o-glucoside showed a significant protective effect on indomethacin-induced gastric ulcer in mice in a dose-dependent manner. In addition, in vitro and cyclic dichroism studies confirmed that tamarisin-3-o-glucoside inhibited the activity of the enzyme matrix metalloproteinase 9(MMP-9) with an IC50 value of 50 μmol. Molecular docking and kinetics indicate that Tamarix-3-o-glucoside binds into the pocket of MMP-9 active site, forming a coordination complex with catalytic zinc, resulting in MMP-9 inhibition of activity. |